ALDH2: the alcohol flush
G/A → Reduced clearance, flush-prone
Re-analysis of the genome you already own · read in Finland
Your genome doesn't change. The science does.
You already have the file. Aimosti turns it into a report you can check line by line: what it found, what it means, and what it could not see. It reads a 23andMe export or a whole genome against this month's ClinVar, CPIC and GWAS Catalog, and shows you the coordinate, the call and the guideline behind every line. When the science moves, it reads your file again. It never sequences, and it never diagnoses.
Drop a file to read it here· 23andMe, AncestryDNA, MyHeritage, FamilyTreeDNA, LivingDNA · VCF, gVCF · BAM, CRAM
Read on your device. Nothing is uploaded, no account is made.
Reading on your device…
That's . We can build your report from it.
What it can tell you
What it can't
A chip reads a fixed set of common spots, so the rare-variant panels need a sequenced genome. We tell you this now rather than after you have paid.
One-time, yours to keep. Your file is still on your device: you upload it after checkout, over an encrypted connection, to storage in Finland.
That's : aligned reads.
This is exactly what the Deep Read pharmacogenomic panel needs: 29 targets read at base level, including the CYP2D6 star-alleles a normal VCF cannot reliably call. The standard report is built from a VCF/gVCF, so aligned reads sit alongside one rather than replacing it.
Deep Read needs standard-depth reads. A low-pass file, MyHeritage's own sequencing download among them, is read about twice over rather than thirty times, which is too thin to call these genes from. We measure the depth and stop rather than guess.
A CRAM also needs the exact reference assembly it was compressed against, not merely the same genome build. We hold the common ones and check yours before taking any money, so an assembly we cannot read is refused rather than charged for.
What the pair covers
The bundle is the whole-genome report plus the Deep Read panel. The report is built from a variant file and the panel from your reads, so it takes both. Most sequencing providers hand you both in the same download.
Nothing was uploaded, and you have not paid anything. We would rather turn a file away here than sell you a report it cannot support.
This check ran on your device from your file's header. We confirm the full file after upload, and never charge for a report we cannot build.
482,198 classified ClinVar variants in our regions
1,042 regions of GRCh38
from €2 chip · €2 genome · €2 Deep Read
Restated from
ClinVar·ACMG SF·CPIC·GWAS Catalog·gnomAD·PhyloTree
Attributed, or not in the report
Nothing in your report is our opinion.
What Aimosti does
- Re-analyses variant data you already own (a chip export or a whole genome)
- Restates ClinVar, ACMG SF, CPIC, GWAS Catalog & PhyloTree, pinned to a version
- Shows evidence and effect on two separate axes, never one score
- Names the gaps: what a variant file cannot tell you
- Re-runs as the databases improve (subscription)
What Aimosti never does
- Take a sample, sequence, test, or diagnose
- Invent a gene or variant association on our own authority
- Collapse weak evidence into a confident-looking number
- Sell, share, or mine your data
- Report MTHFR or APOE as a clinical finding (we explain why)
Modules
Everything our panels read from a variant file.
Each module is anchored to an authoritative, version-pinned source. The speculative modules are walled off from the clinical ones, so curiosity never wears the authority of settled science.
ClinVar / ACMG SF v3.3
Clinical findings
Pathogenic / likely-pathogenic variants in an established actionable-gene panel, framed as personal risk, never a verdict.
ACMG Tier 3 + ACOG carrier panel
Carrier status
A recessive-lens look at carrier variants in your file, for family planning, with the un-callable conditions named.
CPIC guidelines
Pharmacogenomics
How your genotype may affect specific medicines, restating CPIC, to discuss with a prescriber.
GWAS Catalog
Traits
Benign, well-replicated, genome-wide-significant traits that clear a strict evidence gate. No SNPedia folklore.
PhyloTree
Ancestry · maternal & paternal
Your deep maternal and paternal lines as global haplogroups, one thread of your tree, never a "percent ancestry" figure.
credibility firewallbelow it: labelled exploratory, never clinical
Expanded · exploratoryEmerging research
Frontier
Dozens of readings from the interesting edge of the science: alcohol-flush and caffeine metabolism, the natural short-sleeper genes, longevity curios, and the over-hyped classics we keep in to set the record straight (the “warrior gene”, the serotonin-transporter “depression gene”). Each one is labelled by how much it weighs.
Just for funSpeculative · curiosity only
The Fringe
The playful gene-quirks people love to look up (why coriander can taste of soap, red hair, spicy-food tolerance, even the genetics of rage at chewing sounds), labelled, bluntly, as for curiosity only.
Alcohol flush, caffeine, the short-sleeper genes.
Everyone else either hides the speculative stuff or sells it as gospel. We show dozens of the variants you actually want to see, each wearing a blunt evidence tier, from replicated down to contested.
01# re-analysis · what changed · sources: ClinVar 2026-07, CPIC, GWAS Catalog
02＋ NEW ClinVar reclassified a variant in your file to Likely pathogenic.
03~ UPDATED A Frontier association gained a replication cohort.
04· STABLE Everything else unchanged since your last report.
05# raw reads: none retained · variant extract: panel-restricted · delete on request
The report you bought, kept current.
Databases improve every month. Keep just your small normalised variant file and its ancestry marker extract with us, never raw reads, and we silently re-match them as the literature moves, then tell you plainly what changed. Withdraw any time; your last report is always yours. Keep your report current for €29 a year, or stop and keep the last one.
€29/yr · raw reads never retained
Where your data goes, and where it stops
Your genome is the most personal data there is. It is treated that way.
Your devicefree check · nothing leaves
Helsinki, Finlandread against the sourcesEU only · Art. 9 consent
Aligned readsdeleted the moment coverage is computed
Variant filepurged within 7 dayskept only if you subscribe
Your reportyours to keep · PDFre-read on subscription
Deleteeverything, one request
- Your devicefree check · nothing leaves
- Helsinki, Finlandread against the sources · EU only · Art. 9 consent
- Aligned readsdeleted the moment coverage is computed
- Variant filepurged within 7 days · kept only if you subscribe
- Your reportyours to keep · PDF · re-read on subscription
- Deleteeverything, one request
EU onlyStored and processed in Finland
Stored in servers in Helsinki. Your genome never leaves the EU.
Art. 9Explicit, revocable consent
Genetic data is special-category under GDPR. One explicit consent processes your file and produces your report; research and marketing stay separate and optional, every choice withdrawable, auditable, and versioned.
CryptoEncrypted, never sold
Encrypted in transit. We don't sell, share, or mine your data, ever.
DeleteDeleted on demand
Raw reads are purged after analysis. Subscribers keep a small normalised variant file and its ancestry marker extract, and only if they ask us to. Delete everything with one request.
What your file can light up
Pay once. The report is yours, and you can keep it current if you choose.
Pick where to start. Every report is a one-time purchase you own forever. The strip on each card is the panel, lit where that file can be read. To keep it current as the science moves, add the re-analysis subscription for €29 a year. Compare plans →
Genotyping chip
Chip report
€2one-time
For 23andMe, AncestryDNA, MyHeritage, FamilyTreeDNA, LivingDNA and similar genotyping-array exports: everything your chip can call, fully attributed. Carrier status and the full clinical panel need whole-genome data. MyHeritage kits sold since October 2025 may be sequenced rather than typed on an array, so check which file you have.
- Clinical findings your array covers
- Pharmacogenomics for the genes your chip typed and resolved
- Traits, ancestry & the Frontier module
- Plain-language explainers & PDF
Grow into it: upgrade to the full WGS report for €1 whenever you’re ready.
Most complete report
Whole genome
Full report (WGS)
€2one-time
Every module over your whole-genome file: the deepest read of the genome you already own.
- Clinical, carrier, PGx, traits, ancestry
- Frontier exploratory module
- Plain-language explainers & PDF
- Pinned, attributed sources
The full clinical-findings panel and carrier status live here. A chip file cannot give you either.
From your aligned reads
Deep Read
€2one-time
What only aligned reads (the BAM or CRAM from your provider) can answer: CYP2D6 copy number, a per-gene callability map of exactly what we examined, two deletions called from depth and typed HLA-DQ, on top of the full 29-target pharmacogene panel.
- CYP2D6 copy number and star alleles
- Per-gene callability, measured
- Deletions called from depth; HLA-DQ typed
- Reads deleted immediately after
Prepay Deep Read with the WGS bundle to save.
The cheaper option, and what it costs later
Promethease and Genetic Genie read the same public databases we do. The difference is time. They hand you a report frozen on the day you run it, read from the few hundred thousand positions a genotyping chip types. We read your whole genome where you have it, attribute every finding to the guideline it came from, and can re-read your file as those guidelines change. Your report is a one-off purchase and stays yours. Keeping it current as the guidelines move is the optional re-analysis subscription, and you can start or stop that whenever you like.
Named services are described from their public product pages; features change and we don't speak for them. Three years later, that report still says exactly what it said on the day you ran it.
Common questions
Do you sequence my DNA?
No. Aimosti never takes a sample or sequences anything. You bring whole-genome data you already had produced; we re-analyse the variant file.
Is this a medical test or diagnosis?
No. Every finding is a literature match against public databases: information to discuss with a clinician and confirm with a validated gene test. It is never a diagnosis or medical advice.
What files do you accept?
A whole-genome gVCF gives the most complete report: it records which regions your sequencing covered, so "not found" can mean "examined and clear" rather than merely absent. A plain VCF also gives the full report, read as variant-only. Nebula Genomics, Dante Labs, Sequencing.com and the like are good to go. Several of them, Nebula, Gencove and Dante among them, only ship a variant-only VCF; that still gives the full report, so upload what you have. Check which depth you bought, though: a whole-genome product can be sold at 1x or 2x as well as at 30x. A low-pass genome is imputed against a reference panel rather than read directly, which is good for ancestry, traits and pharmacogenomics and cannot carry the clinical-findings and carrier panels, so it is the €2 report rather than the €2 one. Genotyping-array raw data from 23andMe, AncestryDNA, MyHeritage, FamilyTreeDNA or LivingDNA works too, for a lighter report (traits, pharmacogenomics and ancestry); clinical findings and carrier status need a sequenced genome. MyHeritage kits sold since October 2025 are sequenced rather than typed on a chip, and the raw-data export they hand you still works here.
Where does my data live?
Stored in Finland (Helsinki), never leaving the EU, never sold or mined, deleted on demand. Security & your data →
The genome you already own has more to say.
One living report, many modules. Read in Finland, attributed to the source, yours to keep.
Get your report · €2